Eating disorders, especially obesity, are one of the most common causes of various diseases in industrialized societies around the world, especially cardiovascular diseases with permanent disability or fatal consequences, such as heart attack, diabetes or stroke. The Robert Koch Institute reported in 2021 that 67% of men and 53% of women in Germany are overweight. 23 percent of adults are severely overweight (obese). Attempts to influence eating behavior with drugs have so far proved ineffective. A new therapy that modulates the excitability of neural networks that control eating behavior would be a decisive step in controlling this widespread obesity. A group of nerve cells in the hypothalamus controls the release of endogenous lysophospholipids, which in turn control the brain, according to a research paper published in the journal Nature Metabolism. The excitability of cortical nerve cells, thereby stimulating food intake.
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