The following are the biomedical technology developments that I am looking forward to in 2023:
1. Human clinical data readout of RNAi targeting the lung.
2. Human clinical data readout of RNAi targeting the brain.
3. Further progress in RNAi targeting muscle tissue.
4. Human gene editing inserts genes into human clinical trials for the first time, and base editing human clinical trial data is read out.
5. Read out the effect data of PROTAC on multiple targets.
6. BCMA-CART is successful in the 2-4 line phase III clinical data in MM.
7. Clinical data readout of camptothecin ADC for multiple targets.
8. Read out the clinical data of RNAi combined with monoclonal antibody and interferon in the treatment of hepatitis B.
9. Read out the clinical data of TCR therapy in solid tumors and HBV.
10. The first CRISPR gene editing therapy was approved for marketing.
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