Researchers at Florida State University College of Medicine found that aspartame was linked to anxiety behavior in mice. Mice that ate aspartame developed anxiety, and the effects lasted two generations from male mice exposed to the sweetener. The US Food and Drug Administration (FDA) approved aspartame as a sweetener in 1981. Today, nearly 5,000 metric tons are produced annually. When consumed, aspartame turns into aspartic acid, phenylalanine, and methanol, all of which can have powerful effects on the central nervous system. The researchers gave mice drinking water containing aspartame, which contained about 15 percent of the FDA-approved maximum daily intake for humans. In a four-year study, this dose was equivalent to drinking six to eight 8-ounce cans of diet soda per day for 12 weeks in humans.
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