The delivery systems of Aibo and Lanque are different.
The delivery system used by Professor Lin is exactly the same as that of Moderna, and has obtained a memorandum of understanding from the Canadian company. This delivery system can only be used in the research and development of the new crown, and cannot be used in other vaccines.
Expro’s delivery system was invented by InBev itself. This technology has its advantages and disadvantages: There are two main reasons why Aibo’s first-generation seedlings have higher fever than ordinary seedlings. The first problem is that Aibo did not modify the front end of the new coronavirus gene sequence with uracil . The second is the amount and variety of the delivery system, which has a certain relationship with fever. But the advantage of this packaging technology and delivery system is that the vaccine can be stored at two to eight degrees, while the vaccine of Lanque Biotech should be stored at minus 20 degrees. Aibo’s delivery technology is its own intellectual property, and there is no problem with patents.
The half-life (stability) of the antibody is basically 11 months according to the data of Aibo, which is estimated to be comparable to that of Aibo.
It takes 5-14 days for the in vivo degradation of the blue magpie biological vaccine to be completely metabolized, and it takes 14 days for the metabolism to completely return to zero, which has no effect on safety.
Abbott’s mRNA vaccine is injected into the human body and stimulates cytokines to cause fever after entering the cells, so basically it starts to work in six hours, and the fever disappears after 24 hours to 72 hours. It usually disappears completely in 48 hours . The seedlings of blue magpie should be better than those of Aibo, and the fever of blue magpie is about 1/5 of that of Aibo.
Modena’s antigen content is 100 micrograms per dose, and Pfizer’s is 30 micrograms per dose. It should be said that Modena’s safety response is much heavier than Pfizer’s, but its effectiveness is much better than Pfizer’s. Persistence, so Modena (published in the article) should be effective if its stability can last for eight to ten months, but Pfizer’s persistence can’t reach eight to ten months, the reason is the problem of antigen content. The single dose of Aibo Bio is 15 micrograms.
Everyone thinks that S protein is far better than RBD, but it is actually a wrong idea. InBev’s packaging technology can’t wrap a long chain protein as long as S protein, so he found a trick. The decision point of S protein is RBD, and the decision point of new crown is S protein. The protein chain length of RBD is about 1/ of that of S protein. 6. This technology is reliable and no problem. For Delta virus prevention and control, RBD technology is better than S protein, why? That is, although RBD is not a full-length S protein, and its antigenic epitope site is not as complete as that of S protein, the antigen concentration of RBD is six times that of S protein because it is 1/6 in length. For delta virus RBD is better than full-length protein, Watson Bio has made it. Therefore, Qin Chengfeng said that Watson Bio’s first-generation vaccine is four to seven times that of Pfizer’s. This is an antibody true virus test.
Omicron and Watson Bio found that full-length S protein is better than RBD. Therefore, RBD has the advantage of RBD, and S full-length protein has the advantage of full-length S protein.
mRNA is an industrial revolution, mRNA has actually changed human beings. Nucleic acid vaccines are the top vaccines, but nucleic acid vaccines have a huge safety problem, which is why countries do not approve them. Because the nucleic acid vaccine must enter the nucleus, but gene integration may occur if it enters the nucleus, which creates a biosafety problem. But mRNA is different. The mRNA vaccine does not enter the nucleus, does not need to be deoxygenated, and directly enters the cytoplasm, where it directly expresses and translates the antigenic protein. Strictly speaking, the mRNA vaccine we make should not be called an antigen. The substance we call cell signal is injected into it, and we call it chicken hair letter. The chicken feather letter is typed in to induce the body to produce a synthetic reaction protein and produce antibodies.
The toxicity of the vaccine is related to both the mRNA and the delivery system.
If the dose is strong, there must be a response in terms of safety. How to handle this? Modena 100 micrograms is definitely not the best choice for antigen content, but he has done experiments.
The amount of antigen content has nothing to do with the content of the delivery system. The content of the delivery system is the same. For example, 100 micrograms and 30 micrograms may be the same in the delivery system, including the content. In addition, the delivery technology is also related to the production equipment. Watson Bio’s mRNA production line is as advanced as Merck’s production line, comparable to it, and domestic counterparts may not even be able to dream of it.
Aibo’s technology has all been transferred to Watson Bio. This set of packaging technology equipment demonstrates the intelligence of InBev.
In the design and processing of gene sequences, the level of Lanque Biology is higher than that of InBev, and the layer delivery technology is better than InBev, but it is authorized by others, not created by him, and this delivery system cannot be used for blisters or Get a flu shot. However, Professor Lin is also studying this layered technology, which will be solved in the future for herpes and flu vaccines.
Watson Bio is now working hard to communicate with CDE, and the Academy of Military Sciences will also assist. Professor Lin is the tutor of CDE.
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