A research team at the Leipzig University Faculty of Medicine has discovered a new mechanism associated with severe obesity in children. This genetic rearrangement led to abnormal expression of a gene involved in hunger control that was missed by most conventional genetic tests for obesity. The findings were published in the journal Nature Metabolism. While studying tissue samples from a severely obese girl, researchers at the University of Leipzig discovered that a specific gene, the agouti signaling protein (ASIP) gene, cells) produced in large quantities.
The research team identified four other patients with the same mutation.
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