A study published in the journal Human Reproduction has found that the sperm epigenetic aging clock may be a new biomarker for predicting the timing of a couple’s pregnancy. Sperm epigenetic aging is the physiological aging of sperm, rather than temporal aging. The study found that couples with older male partners had a 17 percent lower cumulative chance of conceiving after 12 months than couples with younger male partners. The study involved 379 male partners who had stopped using contraceptives in order to conceive. The study also found that men who smoked had a higher degree of apparent aging in their sperm. While the chronological age of both partners remains an important predictor of reproductive success, the sperm epigenetic aging clock likely reflects both external and internal factors driving sperm biological aging.
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