At the beginning of the monkeypox epidemic, a man in his 20s came to the emergency room in Northern California with small blisters on his lips, hands and back. Within 12 hours, he was diagnosed with monkeypox by doctors. But that’s all doctors can be sure of. The patient had no fever, malaise, weakness, pain, or other symptoms typical of the disease. He also doesn’t know when or how he got infected. He said he hadn’t had sexual contact with anyone in months, and to his knowledge had not touched anyone with the rash or other symptoms. Early in the outbreak, scientists thought they knew when and how the monkeypox virus spread, the symptoms of the disease and who was most vulnerable. But the 47,000 confirmed cases globally defied many of their expectations .
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